Mouse inbred strain differences in ethanol drinking to intoxication
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چکیده
منابع مشابه
Mouse inbred strain differences in ethanol drinking to intoxication.
Recently, we described a simple procedure, Drinking in the Dark (DID), in which C57BL/6J mice self-administer ethanol to a blood ethanol concentration (BEC) above 1 mg/ml. The test consists of replacing the water with 20% ethanol in the home cage for 4 h early during the dark phase of the light/dark cycle. Three experiments were conducted to explore this high ethanol drinking model further. In ...
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If we conduct the same experiment in two laboratories or repeat a classical study many years later, will we obtain the same results? Recent research with mice in neural and behavioral genetics yielded different results in different laboratories for certain phenotypes, and these findings suggested to some researchers that behavior may be too unstable for fine-scale genetic analysis. Here we expa...
متن کاملEvaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice.
Because of intrinsic differences between humans and mice, no single mouse model can represent all features of a complex human trait such as alcoholism. It is therefore necessary to develop partial models. One important feature is drinking to the point where blood ethanol concentration (BEC) reaches levels that have measurable affects on physiology and/or behavior (>1.0 mg ethanol/ml blood). Mos...
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متن کاملStrain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests.
Mice from 8 to 21 inbred strains were tested for sensitivity to ethanol intoxication using a range of doses and three different measures: the screen test, the dowel test and a test of grip strength. Strains differed under nearly all conditions. For the dowel test, two dowel widths were employed, and mice were tested immediately or 30 min after ethanol. For the dowel and screen tests, low doses ...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2007
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2006.00210.x